10X single cell RNA- and feature barcode sequencing of 38 AML samples
This dataset contains fastq-files from single cell 3’ RNA- and feature barcode sequencing of AML samples using 10X technology (Chromium Single Cell 3ʹ Reagent Kit v3). In total, the dataset contains data from 38 AML samples from either bone marrow or peripheral blood, representing the following genetic subtypes: NPM1-mutated, myelodysplasia related, TP53-mutated, CBFB::MYH11, RUNX1::RUNX1T1, AML without class-defining mutations, and AML meeting criteria of two subtypes. The data consists of sequenced gene expression libraries from 38 samples and feature barcoding libraries covering a panel of 10-14 surface proteins for 34 samples.
This dataset is 1 of 4 included in the study titled The cellular state space of AML unveils novel NPM1 subtypes with distinct clinical outcomes and immune evasion properties, http://identifiers.org/ega.study:EGAS50000001084.
Official landing page: http://identifiers.org/ega.dataset:EGAD50000001577